Medial and Lateral Orbitofrontal Cortex Metabolic Changes with Deep Brain Stimulation in Obsessive-Compulsive Disorder: An FDG-PET Study

Virtual · May 2021

Posters · Neuroscience

Karianne Sretavan Wong
Massachusetts General Hospital/Harvard Medical School
Amy Peters
Massachusetts General Hospital/Harvard Medical School
Benjamin Greenberg
Brown Medical School/Butler Hospital
Nicole McLaughlin
Brown Medical School/Butler Hospital
Darin Dougherty
Massachusetts General Hospital/Harvard Medical School

Abstract

The orbitofrontal cortex (OFC) is a key area of neural dysfunction in obsessive-compulsive disorder. Using positron emission tomography with 18F-fluorodeoxyglucose, we identified a reduction in metabolic activity in both the medial and lateral OFC following at least three months of deep brain stimulation at the ventral capsule/ventral striatum.

Psychopathology

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Medial and Lateral Orbitofrontal Cortex Metabolic Changes with Deep Brain Stimulation in Obsessive-Compulsive Disorder: An FDG-PET Study

Abstract

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