The Neurobiology of Neuroticism/Negative Emotionality

Neuroticism/negative emotionality (N/NE) confers risk for a panoply of adverse outcomes, yet the underlying neural circuitry has remained unclear. Leveraging a novel combination of neuroimaging and machine learning approaches, we provide evidence that elevated N/NE reflects hyper-reactivity to uncertain threat in the bed nucleus of the stria terminalis.