APS
2022 APS Annual Convention · 2022
Epigenome-Wide Meta-Analysis of Prenatal Maternal Stressful Life Events and Newborn DNA Methylation
- Anna Ruehlmann
University of Cincinnati College of Medicine - Sara Sammallahti
University of Helsinki and Helsinki University Hospital - Andrea P. Cortes Hidalgo
Erasmus MC, Sophia Children’s Hospital - Jari Lahti
University of Helsinki, Faculty of Medicine - Kelly Brunst
Univeristy of Cincinnati College of Medicine
Abstract
This global meta-analysis analyzed epigenome-wide association studies between maternal prenatal exposure to stressful life events and DNA methylation in cord blood from 12 cohorts (N=5,496). Increased exposure to cumulative stress or specific life stressors during pregnancy can impact the epigenome of the developing fetus, as well as affect neurodevelopment.
Stress
