APS
2022 APS Annual Convention · 2022
PTSD, Obesity and Oxytocin: A Network Biology of Metabolic Response to Stress
- Thomas Chacko
Center for Clinical Systems Biology, Rochester General Hospital, Rochester NY - Spencer Richman
Center for Clinical Systems Biology, Rochester General Hospital, Rochester NY - Michelle Costanzo
Complex Exposure Threats Center of Excellence (CETCE), Department of Veterans Affairs, Washington, DC - Jonathan Tory Toole
College of Health Sciences and Technology, Rochester Institute of Technology, Rochester NY - Gordon Broderick
Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY, USA
Abstract
Automated text mining of peer-reviewed literature extracted documented regulatory pathways linking metabolic response to stress with PTSD and obesity. One third of pathways involving two metabolic mediators jointly affected both conditions. While NPY and cortisol imparted divergent effects, oxytocin emerged as a promising therapeutic target for both PTSD and Obesity.
Stress
