Harnessing Brain Microglia to Fight Depression

Chicago, IL · May 2022

Poster · Biological/Neuroscience

Raz Yirmiya
The Hebrew University of Jerusalem, Israel

Abstract

We show that stimulation of brain microglia, via modulation of specific immune/microglial checkpoint genes and the consequent changes in neurogenesis, underlie the antidepressant effects of electroconvulsive therapy (ECT). These findings enabled the development of a novel personalized pharmacological procedure that mimics the effects of ECT on microglia, neurogenesis and behavior.

Mood Disorders

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Harnessing Brain Microglia to Fight Depression

Abstract

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