Association of Childhood Neighborhood Disadvantage with DNA Methylation

Virtual · June 2020

Poster Sessions · Cross-Cutting Theme Poster - Biological Embedding of Early Life Adversity

Aaron Reuben
Duke University
Karen Sugden
Duke University
Louis Arseneault
King's College London
David Corcoran
Duke University
Andrea Danese
King's College London
Helen Fisher
King's College London
Terrie Moffitt
Duke University
Joanne Newbury
King's College London
Candice Odgers
Duke University
Joesph Prinz
Duke University
Line Rasmussen
Duke University
Ben Williams
Duke University
Jonathan Mill
University of Exeter
Avshalom Caspi
Duke University

Abstract

We tested the association of childhood neighborhood disadvantage with adolescent DNA-methylation in a prospective birth-cohort. Children raised in disadvantaged neighborhoods exhibited differential DNA-methylation in genes involved in inflammation, exposure to tobacco-smoke, and metabolism of hydrocarbons. Children raised in disadvantaged neighborhoods enter young-adulthood epigenetically distinct from their more advantaged peers.

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Association of Childhood Neighborhood Disadvantage with DNA Methylation

Abstract

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