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31st APS Annual Convention · 2019

Multi-Trait Polygenic Prediction of Nicotine Dependence

Washington, DC · May 2019

Poster · Clinical Science

  • Victoria Risner
    Emory University
  • Chelsie Benca-Bachman
    Emory University
  • Rohan Palmer
    Emory University

Abstract

The estimated heritability of nicotine dependence (ND) ranges 40-70%, but Polygenic Risk Scores (PRS) calculated for ND have limited utility using only tobacco use GWAS summary statistics. We examined a multi-trait PRS model using known genetic correlates of ND liability and show incremental gains in accuracy and power.

Genetics

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