APS
31st APS Annual Convention · 2019
Neural Correlates of Stress Circuitry in Major Depressive Disorder in Young Adults
- Sarah Perlo
McLean Hospital - Maria Ironside
McLean Hospital - Maria Ironside
Harvard Medical School - Christine Richards
Massachusetts General Hospital - Amelia Moser
McLean Hospital - Nara Nascimento
McLean Hospital - Laura Holsen
Brigham and Women's Hospital - Laura Holsen
Harvard Medical School - Madhusmita Misra
Massachusetts General Hospital and Harvard Medical School - Madhusmita Misra
Harvard Medical School - Jill Goldstein
Harvard Medical School - Jill Goldstein
Massachusetts General Hospital - Diego Pizzagalli
Harvard Medical School - Diego Pizzagalli
McLean Hospital
Abstract
Using fMRI, we examined neural mechanisms in response to acute laboratory stress in young adults with current and remitted major depressive disorder and healthy controls. Hypoactivity was observed in the OFC (p<.02), right hippocampus (p≤.01), left amygdala (p=.02), anterior insula (p<.001, and hypothalamus (p=.03) in stress versus no stress conditions.
Depression
