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APS

31st APS Annual Convention · 2019

Informing the Fetal Programming Hypothesis for Offspring Depression: HPA-Axis Polygenic Risk Interacts with Maternal Prenatal Stress

Washington, DC · May 2019

Poster · Clinical Science

  • Brooke McKenna
    Emory University
  • Constance Hammen
    University of California, Los Angeles
  • Patricia Brennan
    Emory University

Abstract

The interaction of maternal prenatal stress and offspring polygenic risk (i.e., cumulative risk from HPA-axis genes: CRHR1, FKBP5, NR3C1, and BDNF) significantly predicted offspring depression at age 20 (p = 0.02). Offspring with high genetic risk exhibited greater depressive symptoms following maternal prenatal stress than offspring with low genetic risk.

Depression

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