Assessing Social Interaction through Chemogenetic Disruption of the Ventral Hippocampus and Orbitofrontal Cortex

Social behaviors are often perturbed in neuropsychiatric disorders. Neuroimaging studies suggest increased activity in hippocampal and prefrontal cortical regions during socioemotional behavior. Using animal models, we examine the impact of disrupting hippocampal-prefrontal circuitry. In this study, we disrupted this pathway using DREADDS then tested animals on a Social interaction task.