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30th APS Annual Convention · 2018

Interaction of Polygenic Risk for Neuroticism and Stressful Life Events on Depression

San Francisco, CA · May 2018

Poster · Clinical Science

  • Emily Hilton
    University of Wisconsin - Madison
  • Jinkuk Hong
    University of Wisconsin - Madison
  • Qiongshi Lu
    University of Wisconsin - Madison
  • Jan Greenberg
    University of Wisconsin - Madison
  • Marsha Mailick
    University of Wisconsin - Madison
  • Eun Ha Namkung
    University of Wisconsin - Madison
  • James Li
    University of Wisconsin- Madison

Abstract

We examined the interaction of polygenic risk for neuroticism (NE) and adverse and enriched environments on symptoms of depression in the Wisconsin Longitudinal Study. A significant gene-environment interaction was detected; individuals with high PRS for NE were more vulnerable to SLE (more depression) relative to individuals with low PRS.

Psychopathology

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