Dopamine Polymorphisms C957T and COMT Interact to Increase Flexibility in the Iowa Gambling Task

We examined the Iowa Gambling Task and polymorphisms COMT and C957T, which influence dopamine in the prefrontal cortex and striatum, respectively. This task requires both stable maintenance and flexible updating of information. We found that the combination of C957T TT homozygosity and COMT Val/Val homozygosity led to increased cognitive flexibility.