A Functional BDNF Polymorphism Moderates the Association Between Corticolimbic White Matter Microstructure and Trait Anxiety in Women but Not Men

Prior research links corticolimbic white matter microstructure with trait anxiety, particularly in women. Here, we first replicate this association in women specifically, and second demonstrate its moderation by functional genetic variation in a neurodevelopmental pathway. Our results provide a window onto genetically driven variability in sex-specific brain-behavior associations.