Effect of Fluoxetine on Dendritic Arborization of the Prefrontal Cortex and on Depression-Related Behaviors In CD1 Mice Subjected to Chronic Mild Unpredictable Stress

We examined the effects of chronic mild unpredictable stress and fluoxetine on prefrontal dendritic arborization and depression-related behaviors in CD1 mice. Thirty-six animals (18 males, Mage = 45 days) underwent an 8-week protocol. Fluoxetine partially reversed stress-induced behavioral deficits and dendritic atrophy, supporting its role in restoring neuroplasticity.