P300 Amplitude during Emotion Suppression Provides Distinct Neural Markers for PTSD and GAD

We examined P300 as a potential neurophysiological marker for PTSD and GAD (N = 278). Reduced P300 amplitude during emotion regulation reliably predicted PTSD diagnosis, while increased P300 amplitude showed a weak link to GAD. Findings suggest P300 suppression may reflect trauma-specific emotion regulation deficits rather than generalized anxiety.