Cognitive Intra-Individual Variability Predicts Regional Heterogeneity In Alzheimer’s Disease Biomarkers

Barcelona, Spain · May 2026

Posters · Brains, Bodies & Behavior

Min Huey Teo
Psychology, Nanyang Technological University
Malcolm Taong
Psychology, Nanyang Technological University
Cheuk Ni Kan
Psychology, Nanyang Technological University
Chin Hong Tan
Psychology, Nanyang Technological University
Chin Hong Tan
Lee Kong Chian School of Medicine

Abstract

We examined whether cognitive intra-individual variability (IIV) predicts regional heterogeneity in amyloid, tau, and cortical thickness. Cognitive IIV was associated with biomarker IIV across all modalities, including among tau-negative individuals, with stronger effects in MCI and biomarker-positive groups. Cognitive and biomarker variation-based metrics likely reflect common disease processes in AD.

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Cognitive Intra-Individual Variability Predicts Regional Heterogeneity In Alzheimer’s Disease Biomarkers

Abstract

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