APS
2026 APS Annual Convention · 2026
Cerebral Frailty for Dementia Risk Prediction
- Cheuk Ni Kan
Psychology, Nanyang Technological University - Justin Chew
Institute of Geriatrics and Active Aging - Justin Chew
Geriatric Medicine, Tan Tock Seng Hospital - Wee Shiong Lim
Lee Kong Chian School of Medicine - Wee Shiong Lim
Geriatric Medicine, Tan Tock Seng Hospital - Wee Shiong Lim
Institute of Geriatrics and Active Aging - Chin Hong Tan
Lee Kong Chian School of Medicine - Chin Hong Tan
Psychology, Nanyang Technological University
Abstract
This study examined the interplay between frailty and cerebral dysfunction on dementia risk. Multiple brain aging markers were associated with frailty, jointly increasing dementia risk. A machine learning model integrating frailty and multimodal neuroimaging demonstrated high predictive accuracy, offering a potential tool for early detection and intervention for elevated-risk individuals.
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