Understanding the Natural Landscape of the Chronology of Major Depressive Disorder and Mania in Youth

Virtual · October 2025

Poster · Clinical Science

Maria Iorini
Massachusetts General Hospital/Harvard Medical School
Maura DiSalvo
Massachusetts General Hospital
Gagan Joshi
Harvard Medical School
Gagan Joshi
Massachusetts General Hospital/Harvard Medical School
Janet Wozniak
Harvard Medical School
Janet Wozniak
Massachusetts General Hospital
Mai Uchida
Harvard Medical School
Mai Uchida
Massachusetts General Hospital

Abstract

We examined 2,947 pediatric referrals. Of patients with mood disorders (n=1357), 60% had only depression, 7% only mania, and 33% both. Among the comorbid group, 29% had depression first, 32% mania first, and 39% concurrent onset—highlighting the variable trajectory of mood disorders in youth

Mood Disorders

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Understanding the Natural Landscape of the Chronology of Major Depressive Disorder and Mania in Youth

Abstract

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