Maternal Neuroimmune Activity During Pregnancy and Infant’s Mental and Motor Development

We explored how maternal neuroimmune activity during pregnancy shapes infant development (N=1,395). Maternal BDNF and IL-2 (anti-inflammatory) were associated with better cognitive and motor outcomes, while elevated IFNy (pro-inflammatory) was linked to poorer mental development. Findings highlight the importance of immune balance and neurotrophins for healthy offspring development.