Newly Engineered Mouse Lines Reveal Rules for Psychedelic Neuroplasticity in Brain Regions Lacking 5-HT2a Receptors

Name: Newly Engineered Mouse Lines Reveal Rules for Psychedelic Neuroplasticity in Brain Regions Lacking 5-HT2a Receptors
Start: 2025-05-25T00:00:00+00:00
Location: Washington, DC

Sunday, May 25, 2025 · Washington, DC

Oral · Biological/Neuroscience

Psychedelic therapy is thought to work by boosting neuroplasticity onto prefrontal neurons expressing serotonin 2A receptors (5-HT2AR). We engineered new conditional knockout mouse lines to reveal psychedelic neuroplasticity of regions lacking 5-HT2AR. Physiology from 321 neurons (84 mice) causally revealed a presynaptic, not postsynaptic, basis of psychedelic neuroplasticity.

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Omar AhmedSpeaker
University of Michigan

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Newly Engineered Mouse Lines Reveal Rules for Psychedelic Neuroplasticity in Brain Regions Lacking 5-HT2a Receptors

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