Integrating Multiple Environmental Systems to Predict Subcortical Brain Volume and Externalizing Psychopathology in Youth

We employed Bayesian latent profile analysis (LPA) to obtain multi-system environment profiles during childhood. We used the profiles to predict subcortical volume and psychopathology during adolescence. Bayesian LPA revealed 9 profiles with excellent discrimination. Three profiles predicted externalizing problems. We found two pathways that predicted externalizing psychopathology via subcortical volume.