Cerebellar Activation during a Working Memory Task and Its Association with General Psychopathology and Overall Executive Function in a Cross-Diagnostic Patient Sample

We examined relations among cerebellar fMRI activation, executive functioning (EF), and the ‘p-factor’ in cross-diagnostic patients. Greater cerebellar activation during increasing working memory task difficulty was associated with higher p-factor scores via poorer EF test performance. EF may be one mechanism underlying associations between cerebellar alterations and general psychopathology.