APS
2025 APS Annual Convention · 2025
Effects of AD Genetic Risk on Cognitive and Brain Trajectories and Attenuation By Cognitive Reserve
- Corinne Pettigrew
The Johns Hopkins University School of Medicine - Anja Soldan
The Johns Hopkins University School of Medicine - Jiangxia Wang
Johns Hopkins Bloomberg School of Public Health - Marilyn Albert
The Johns Hopkins University School of Medicine
Abstract
Analyses examined whether level of cognitive reserve (CR) modified the impact of Alzheimer’s disease (AD) genetic risk on longitudinal cognitive trajectories and brain atrophy. Among individuals who were cognitively unimpaired at baseline, higher CR attenuated APOE-ε4-related declines in cognition and brain atrophy. In contrast, CR did not attenuate AD-PRS-related declines.
