Depression is a Modifiable Risk Factor for Alzheimer’s Disease and Related Dementias

Washington, DC · May 2025

Poster · Clinical Science

Lauren Rutter
Indiana University
Lucas Hamilton
Augustana University
Skylar Wilson
Indiana University, Bloomington
Brea Perry
Indiana University, Bloomington
Anne Krendl
Indiana University, Bloomington

Abstract

Depression and sex influence Alzheimer’s disease. Cox proportional-hazards models examined effects of sex, age, and depression on impairment risk. In 26,362 adults, depression increased impairment risk by 74% in men (HR=1.74, p<.001) and 106% in women (HR=2.06, p<.001). For women, the effect of depression on impairment was significantly larger (p<.01).

Aging

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Depression is a Modifiable Risk Factor for Alzheimer’s Disease and Related Dementias

Abstract

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