Hematopoietic-Specific Deficiency of Duffy Antigen Receptor for Chemokines Promotes Insulin Resistance during Diet-Induced Obesity in Mice

Washington, DC · May 2025

Poster · Biological/Neuroscience

Praneet Veerapaneni
Medical College of Georgia at Augusta University
Ghaith Aboud
Medical College of Georgia at Augusta University
Tyler Benson
University of Cincinnati
Ragheb Harb
Medical College of Georgia at Augusta University
David Kim
Augusta University
Mourad Ogbi
Medical College of Georgia at Augusta University
Nicole Cyriac
Medical College of Georgia at Augusta University
Mehek Sharma
Medical College of Georgia at Augusta University
Hong Shi
Medical College of Georgia at Augusta University
Ha Won Kim
Medical College of Georgia at Augusta University
Neal Weintraub
Medical College of Georgia at Augusta University

Abstract

Chronic inflammation is associated with obesity that originates from increased production of pro-inflammatory chemocytokines. Duffy antigen receptor for chemokines (DARC) plays an important role in regulating chemocytokines. In this study, we found that hematopoietic-specific, but not adipose-specific, deficiency of DARC promotes insulin resistance during diet-induced obesity in mice.

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Hematopoietic-Specific Deficiency of Duffy Antigen Receptor for Chemokines Promotes Insulin Resistance during Diet-Induced Obesity in Mice

Abstract

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