APS
2025 APS Annual Convention · 2025
Hematopoietic-Specific Deficiency of Duffy Antigen Receptor for Chemokines Promotes Insulin Resistance during Diet-Induced Obesity in Mice
Session: Poster Session I
Authors
- Praneet VeerapaneniPresenting Author
Medical College of Georgia at Augusta University - Ghaith Aboud
Medical College of Georgia at Augusta University - Tyler Benson
University of Cincinnati - Ragheb Harb
Medical College of Georgia at Augusta University - David Kim
Augusta University - Mourad Ogbi
Medical College of Georgia at Augusta University - Nicole Cyriac
Medical College of Georgia at Augusta University - Mehek Sharma
Medical College of Georgia at Augusta University - Hong Shi
Medical College of Georgia at Augusta University - Ha Won Kim
Medical College of Georgia at Augusta University - Neal Weintraub
Medical College of Georgia at Augusta University
Abstract
Chronic inflammation is associated with obesity that originates from increased production of pro-inflammatory chemocytokines. Duffy antigen receptor for chemokines (DARC) plays an important role in regulating chemocytokines. In this study, we found that hematopoietic-specific, but not adipose-specific, deficiency of DARC promotes insulin resistance during diet-induced obesity in mice.
Other
