Influence of Perceived Racial Discrimination As a Chronic Stressor on Prefrontal Cortical Function in Adolescents

We examined how self-reported racial discrimination impacts prefrontal functioning in 5727 adolescents. Discriminated vs nondiscriminated youth showed diminished prefrontal activity and executive functioning, but no differences in visual cortical activity. These findings highlight sensitivity of the prefrontal cortex to social stressors and need for changes that support equitable brain development.