APS
2023 APS Annual Convention · 2023
Greater Estimated Disease Burden for Huntington's Disease Worsens Memory and Executive Functioning in Novel Cognitive Assessments
- Alex Pinto
University of Wisconsin - Madison - Alicia Henson
University of Wisconsin-Madison - Nathaniel Houghtaling
University of Wisconsin-Madison - Maria Rudrud
University of Wisconsin-Madison - William Adams
Loyola University Chicago - Katherine Possin
University of California-San Francisco - Roland Zschiegner
University of Wisconsin-Madison - Jane Paulsen
University of Wisconsin-Madison
Abstract
We analyzed performances on novel iPad-based assessments between at-risk gene-negative controls and non-diagnosed participants carrying the gene expansion causing Huntington's Disease. Memory and executive functioning showed worsening in participants with greater estimated disease burden (based on genetic mutation and current age; CAP score) significantly worse for high-risk participants.
Memory
