APS
2023 APS Annual Convention · 2023
Weighing the Genetic Risk: Associations between Polygenic Risk Scores for Cardiometabolic Phenotypes and Adolescent Depression and Body Dissatisfaction
- Krista Ekberg
Rosalind Franklin University of Medicine and Science - Giorgia Michelini
Queen Mary University of London - Kristin Schneider
Rosalind Franklin University of Medicine and Science - Roman Kotov
Stony Brook University, The State University of New York - Daniel Klein
Stony Brook University, The State University of New York - Monika Waszczuk
Rosalind Franklin University of Medicine and Science
Abstract
This study tested whether BMI accounts for associations between polygenic risk scores (PRS) for cardiometabolic traits, and phenotypic depression and body dissatisfaction in adolescents. Polygenic prediction of depression and body dissatisfaction was mediated by BMI in all models, except for the association between PRS for type 2 diabetes and depression.
Mood Disorders
