Assessing Changes in Irritability Longitudinally in Presymptomatic Huntington's Disease Gene Expansion Carriers

Washington, DC · May 2023

Poster · Biological/Neuroscience

Alicia Henson
University of Wisconsin-Madison
Cara Joyce
Loyola University Chicago
Mariah Rudrud
University of Wisconsin-Madison
Alex Pinto
University of Wisconsin - Madison
Nathaniel Houghtaling
University of Wisconsin-Madison
Jane Paulsen
University of Wisconsin-Madison

Abstract

We analyzed longitudinal data on irritability symptoms from the multisite observational Predict-HD study on 294 participants carrying the gene expansion that causes Huntington's Disease. Inward and outward irritability scores were stable over one year and correlated with depression and anxiety but not cumulative exposure to mutant huntingtin protein (CAP score).

Mood Disorders

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Assessing Changes in Irritability Longitudinally in Presymptomatic Huntington's Disease Gene Expansion Carriers

Abstract

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