Age of Memory and Reconsolidation: Cycloheximide Disrupts Reconsolidation of Recent and Remote Appetitive Odor Discrimination Memory in Rats

Consolidated memories become vulnerable to disruption through protein synthesis inhibition (e.g., cycloheximide), but only when memory is first reactivated. An odor discrimination memory was reactivated 1 or 72 days post-training, followed by cycloheximide or saline intraperitoneal injection. Cycloheximide decreased odor discrimination memory for both recent and remote memory.