Common Genetic Risk for Obesity Is Associated with Exaggerated Differential Brain Activity in Response to Positive and Negative Feedback

Here, using a well-powered sample we provide novel evidence that a common polymorphism (FTO rs9939609), previously associated with obesity and weight gain, is associated with functional alterations throughout a novel distributed circuit. These patterns suggest that obesity-risk associated with FTO may reflect genetic effects on more general reward-related brain function.