Structural Alterations within Cerebellar Circuitry Are Associated with General Liability for Common Mental Disorders

We examined structural neural correlates of a general psychopathology factor in a large sample of young adults. We identified reduced cortico-cerebellar white matter integrity and gray matter volume as transdiagnostic correlates, suggesting that this circuitry supporting basic information integration, coordination, and monitoring may contribute to general liability for psychopathology.