APS
29th APS Annual Convention · 2017
Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently from Amyloid Accumulation in Older Adults
- Jennifer Rabin
Massachusetts General Hospital - Rodrigo Perea
Massachusetts General Hospital - Rachel Buckley
University of Melbourne - Rachel Buckley
Massachusetts General Hospital - Keith Johnson
Massachusetts General Hospital - Reisa Sperling
Brigham and Women’s Hospital - Reisa Sperling
Massachusetts General Hospital - Trey Hedden
Massachusetts General Hospital
Abstract
We examined whether diffusion characteristics of global versus tract-specific white matter predict longitudinal cognitive decline in healthy older adults. Diffusion imaging was performed at baseline. Cognition was examined longitudinally (up to 6 years). Linear mixed models found that global, rather than tract-specific, white matter predicted longitudinal changes in cognition.
Cognitive Neuroscience
