Depression is a Modifiable Risk Factor for Alzheimer’s Disease and Related Dementias

Poster Session II

Friday May 23, 2025 (10:30 - 11:30 ET)
Keyword: Aging

Abstract: Depression and sex influence Alzheimer’s disease. Cox proportional-hazards models examined effects of sex, age, and depression on impairment risk. In 26,362 adults, depression increased impairment risk by 74% in men (HR=1.74, p<.001) and 106% in women (HR=2.06, p<.001). For women, the effect of depression on impairment was significantly larger (p<.01).