Tonic and Phasic Irritability Associate with Depression Diagnosis, Symptoms, and Subtypes

Using nationally representative data, our generalized linear models, Cox proportional hazard model, and latent class regression found that phasic and tonic irritability differentially related to almost all aspects of depression in adults. Specifically, tonic irritability showed overall stronger associations with various depressive features, whereas phasic irritability marked higher depressive severity.