ICPS
2021 APS Virtual Convention · 2021
Metabolic Changes in the Orbitofrontal Cortex with Citalopram in Bipolar Depression
- Marta Migó
Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School - Karianne Wong
Massachusetts General Hospital/Harvard Medical School - Darin Dougherty
Massachusetts General Hospital/Harvard Medical School - Nassir Ghaemi
Tufts University School of Medicine
Abstract
We used positron emission tomography to inquire how citalopram changes metabolic activity within the orbitofrontal cortex (OFC) in 12 individuals with BD, after 6 weeks of treatment. Regression analyses revealed that depression severity predicted greater left OFC metabolic activity, and OFC reduced metabolic activity after treatment.
Mood Disorders
