Frontotemporal lobar degeneration (FTLD) is a devastating disease that profoundly changes emotion, self, and personality while initially sparing many aspects of cognitive functioning. This article reviews research that applies methods from basic affective science to obtain a more precise view of FTLD's impact on emotional functioning. This research indicates that simple forms of emotional reactivity are relatively preserved in the early stages of the disease. In contrast, more complex emotional processes, such as those involved with self-conscious emotions (e.g., embarrassment), emotion regulation, and recognizing emotions in others, are severely impaired. FTLD provides rich opportunities for increasing our understanding of the nature of emotion and of the emotional and social brain.

Cognitive aging is often characterized as a process in which two competing forces determine individual development: a genetically driven senescence process that engenders declines in mental mechanics; and an accumulation of life experience that augments cultural, pragmatic, and knowledge-based competence. The considerable variability in the level and rate of change in complex intellectual activities (e.g., language understanding) is often accounted for in terms of individual differences in abilities associated with these forces. I argue that choice in how effort is allocated may be an essential determinant of cognitive change over the life span—both directly, in the form of attentional engagement, and indirectly, as it sculpts neural substrates that give rise to component abilities.

Evidence that adverse rearing environments exert negative effects particularly on children presumed "vulnerable" for temperamental or genetic reasons may actually reflect something else: heightened susceptibility to the negative effects of risky environments and to the beneficial effects of supportive environments. Building on Belsky's (1997, 2005) evolutionary-inspired proposition that some children are more affected—both for better and for worse—by their rearing experiences than are others, we consider recent work on child vulnerability, including that involving measured genes, along with evidence showing that putatively vulnerable children are especially susceptible to both positive and negative rearing effects. We also consider methodological issues and unanswered questions in the differential-susceptibility equation.

Our understanding of short-term recognition memory can be enhanced by careful choice and control of test materials. Theory-driven manipulation of memory test stimuli, including visual textures, human faces, and complex sounds, minimize individual differences and make it possible to predict recognition performance for specific combinations of stimulus items. This stimulus-oriented approach to memory reveals that stimulus similarity plays two different important roles in recognition memory. By exploiting tools used in psychophysics, it is possible to generate mnemometric functions—detailed "snapshots" that capture key features of subjects' memory strength.

Two decades ago, the theory-of-mind hypothesis of autism was introduced by Baron-Cohen and his colleagues; this theory provided a unified cognitive explanation for the key social and communication symptoms in that disorder. I evaluate the theory-of-mind hypothesis in light of studies that have addressed several key questions: Do children with autism develop theory-of-mind concepts? How can we explain why some children with autism pass theory-of-mind tasks? Do deficits in theory of mind account for the major impairments that characterize autistic disorder? Current research supports the view that autism involves delays and deficits not only in the development of a theory of mind but also in additional aspects of social-affective information processing that extend beyond the traditional boundaries of theory of mind.

The United States is becoming increasingly diverse, yet interracial contact continues to be awkward, if not stressful, for many. Indeed, recent research suggests that individuals often exit interracial interactions feeling drained both cognitively and emotionally. This article reviews research examining how interracial encounters give rise to these outcomes, zeroing in on the mediating role of self-regulation and the moderating influence of prejudice concerns. Given that interracial contact may be the most promising avenue to prejudice reduction, it is important to examine factors that undermine positive interracial contact experiences, as well as those that facilitate them.

The body's stress response is an essential adaptive and protective mechanism to cope with threatening situations. However, chronic or traumatic stress leads to structural and functional alterations in the traumatized brain. We argue for a building-block effect: Exposure to different types of traumatic events increases the probability of developing posttraumatic stress disorder (PTSD), via incremental enlargement of a fear network. We summarize evidence of brain changes in PTSD, including recent results from research on animal models of stress-related neuroplastic remodeling, with an emphasis on structural and functional changes in the hippocampus, the amygdala, and the medial prefrontal cortex.

A common perspective on stress-related changes in the human immune system is that such changes are potentially harmful, especially those occurring during chronic stress. In contrast, an ecological perspective views the immune system as an energetically costly system that may or may not have priority over other uses of that energy. From this perspective, the immune system may have energy made available for it via reduction of other activities, may change in energetically conservative ways when the protection it confers needs to be balanced with the energetic demands of other activities such as fight or flight, or may be suppressed when other activities are more important than immunity for total well-being. This last type of change can explain why aspects of psychosocial health such as optimism relate to worse immunity under some circumstances and suggests that both benefits and costs of immunosuppression during stress should be considered in research on human stress and immunity.

Alcohol dependence, drug dependence, childhood conduct disorder, and adult antisocial behavior commonly occur in combination. Data from multiple literatures, including twin/family studies and electrophysiological studies, suggest that the overlap of these disorders is largely due to a shared genetic liability that contributes to a spectrum of externalizing psychopathology. These findings suggest that some genes will not be specific to any one externalizing disorder but will predispose individuals broadly to a spectrum of externalizing psychopathology. Here we review evidence for specific, identified genes, GABRA2 and CHRM2, that follow this pattern and confer risk for a spectrum of externalizing disorders. These findings confirm the etiological structure of psychopathology suggested by psychological research and suggest exciting new roles that psychologists can play in understanding the pathways underlying associations between genes and behavior.

Experimental economics and social psychology share an interest in a widening subset of topics, relying on similar lab-based methods to address similar questions about human behavior, yet dialogue between the two fields remains in its infancy. We propose a framework for understanding this disconnect: The different approaches the disciplines take to translating real-world behavior into the laboratory create a "gap in abstraction," which contributes to crucial differences in philosophy about the roles of deception and incentives in experiments and limits cross-pollination. We review two areas of common interest—altruism and group-based discrimination—which demonstrate this gap yet also reveal ways in which the two approaches might be seen as complementary rather than contradictory.

Synchrony—a construct used across multiple fields to denote the temporal relationship between events—has been applied to the study of mother–infant interaction and is suggested here as a framework for the study of interpersonal relationships. Defined as the temporal coordination of micro-level social behavior, parent–infant synchrony is charted in its development across infancy from the initial consolidation of biological rhythms during pregnancy to the emergence of symbolic exchange between parent and child. Synchrony is shown to depend on physiological mechanisms supporting bond formation in mammals—particularly physiological oscillators and neuroendocrine systems such as those involving the hormone oxytocin. Developmental outcomes of the synchrony experience are observed in the domains of self-regulation, symbol use, and the capacity for empathy across childhood and adolescence. Specific disruptions to the parameters of synchrony that may be observed in various pathological conditions, such as prematurity or maternal affective disorder, are detailed. A time-based, micro-analytic behavioral approach to the study of human relationship may offer new insights on intersubjectivity across the lifespan.

Expertise researchers have traditionally shied away from studying the highest levels of achievement in favor of studying basic cognitive processes, such as memory and categorization. In this article, we present a different approach that is focused on capturing superior (expert) performance on representative tasks that reveal the essential characteristics of expertise in a given domain. In domains where expert performance is measurable, acquisition is gradual and the highest levels are only attained after 10 years of intense preparation—even for the most "talented." Analyses of reproducibly superior performance show that it is mediated by physiological adaptations and cognitive skills acquired as a result of the cumulative effects of special practice activities (deliberate practice). It appears that the genes necessary to attain such adaptations and expert skills can be activated in healthy children—the only clear exceptions to date being genes that control body size and height. Our knowledge of how experts acquire their superior skills provides insights into the potential for human adaptation and skill acquisition and has important implications for theories of the structure of general and expert cognition, as well as for training interventions in applied psychology and education.

Self-control is a central function of the self and an important key to success in life. The exertion of self-control appears to depend on a limited resource. Just as a muscle gets tired from exertion, acts of self-control cause short-term impairments (ego depletion) in subsequent self-control, even on unrelated tasks. Research has supported the strength model in the domains of eating, drinking, spending, sexuality, intelligent thought, making choices, and interpersonal behavior. Motivational or framing factors can temporarily block the deleterious effects of being in a state of ego depletion. Blood glucose is an important component of the energy.