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Poster

Effects of Venlafaxine and Mirtazapine on Morphine-Induced Conditioned Place Preference in the Rats

Poster Session I - Board: I-110
Friday, May 22, 2009, 1:30 PM - 2:30 PM
Yerba Buena 7

Shao-Tsu Chen
Buddhist Tzu Chi General Hospital and University, Taiwan

Sin Chee Chai
Buddhist Tzu Chi University, Taiwan

Shaw-Ji Chen
Buddhist Tzu Chi University, Taiwan

This study investigated whether antidepressants attenuate rewarding effect of 5 mg/kg morphine for rats in conditioned place preference paradigm. The venlafaxine and mirtazapine were injected in a concentration of 10 mg/ml and 25 mg/ml. Significant preferences for the morphine-paired arm were observed except those that with mirtrazapine and vanlafaxine.

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